In the Gamma Ethniki clash on April 18, 2021, Rethymniakos hosted AE Neapolis, showcasing a fierce competition between the two teams. The match, held at Rethymniakos' home ground, saw both sides battling for crucial points in Group 10. After an intense encounter, Rethymniakos emerged victorious, securing a well-deserved win over AE Neapolis.